diff --git a/.gitignore b/.gitignore
index f0e606b..a042636 100644
--- a/.gitignore
+++ b/.gitignore
@@ -8,3 +8,4 @@ biopython-1.54.tar.gz
 /biopython-1.66.tar.gz
 /biopython-biopython-167.tar.gz
 /biopython-1.68.tar.gz
+/biopython-1.69.tar.gz
diff --git a/python-biopython.spec b/python-biopython.spec
index c4b8c3c..4d016a5 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -19,13 +19,16 @@
 %global module biopython
 
 Name:             python-biopython
-Version:          1.68
-Release:          3%{?dist}
+Version:          1.69
+Release:          1%{?dist}
 Summary:          Python tools for computational molecular biology
 Source0:          http://biopython.org/DIST/biopython-%{version}.tar.gz
-License:          MIT
+
+# Starting from biopython-1.69, BioPython is released under the
+# "Biopython License Agreement"; it looks like a MIT variant
+# bz#1440337
+License:          MIT and BSD
 URL:              http://www.biopython.org/
-Group:            Development/Libraries
 
 BuildRequires:    python2-devel
 BuildRequires:    flex-devel
@@ -139,9 +142,10 @@ popd
 ##http://lists.open-bio.org/pipermail/biopython-dev/2014-May/020541.html
 %if 0%{?with_check}
 %check
-pushd python2/Tests
+pushd python2
+export PYTHONPATH=$RPM_BUILD_ROOT%{python2_sitearch}
 find . -name 'run_tests.py' | xargs sed -i '1s|^#!/usr/bin/env python|#!%{__python2}|'
-for test in `ls test_*.py | grep -v Tutorial`; do
+for test in `ls test_*.py | grep -v chapter | grep -v DSSP | grep -v Tutorial`; do
 %{__python2} run_tests.py --offline -v ${test}
 done
 popd
@@ -150,8 +154,9 @@ popd
 %if 0%{?with_python3}
 pushd python3/Tests
 find . -name 'run_tests.py' | xargs sed -i '1s|^#!/usr/bin/env python|#!%{__python3}|'
-for test in `ls test_*.py | grep -v test_Tutorial | grep -v test_NCBIXML | grep -v test_Phylo | grep -v test_SeqIO`; do
+for test in `ls test_*.py | grep -v chapter | grep -v NCBIXML | grep -v Nexus | grep -v Phylo | grep -v SeqIO | grep -v Tutorial`; do
 echo $LANG
+export PYTHONPATH=$RPM_BUILD_ROOT%{python3_sitearch}
 %{__python3} run_tests.py --offline -v ${test}
 done
 popd
@@ -184,10 +189,13 @@ popd
 %license python2/LICENSE
 
 %changelog
+* Wed Apr 12 2017 Antonio Trande <sagitter@fedoraproject.org> - 1.69-1
+- Update to 1.69
+
 * Sat Feb 11 2017 Fedora Release Engineering <releng@fedoraproject.org> - 1.68-3
 - Rebuilt for https://fedoraproject.org/wiki/Fedora_26_Mass_Rebuild
 
-* Mon Dec 19 2016 Miro Hrončok <mhroncok@redhat.com> - 1.68-2
+* Mon Dec 19 2016 Miro Hronok <mhroncok@redhat.com> - 1.68-2
 - Rebuild for Python 3.6
 
 * Sat Aug 27 2016 Antonio Trande <sagitter@fedoraproject.org> - 1.68-1
diff --git a/sources b/sources
index c46a3ba..1769c3d 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-078e915185485a5327937029b7577ddc  biopython-1.68.tar.gz
+SHA512 (biopython-1.69.tar.gz) = 5762f53523950bc5fa53415cda82092f55dd146f5f400005a487607dab9db9fc5194945977a2e5ae14bee0aee85e946847fd2f2477d74b71c30e583f96603c1f