diff --git a/python-crypto-2.6.1-no-distutils.patch b/python-crypto-2.6.1-no-distutils.patch
new file mode 100644
index 0000000..1d1f6c3
--- /dev/null
+++ b/python-crypto-2.6.1-no-distutils.patch
@@ -0,0 +1,78 @@
+--- lib/Crypto/SelfTest/PublicKey/test_DSA.py
++++ lib/Crypto/SelfTest/PublicKey/test_DSA.py
+@@ -223,7 +223,7 @@ def get_tests(config={}):
+         from Crypto.PublicKey import _fastmath
+         tests += list_test_cases(DSAFastMathTest)
+     except ImportError:
+-        from distutils.sysconfig import get_config_var
++        from sysconfig import get_config_var
+         import inspect
+         _fm_path = os.path.normpath(os.path.dirname(os.path.abspath(
+             inspect.getfile(inspect.currentframe())))
+--- lib/Crypto/SelfTest/PublicKey/test_RSA.py
++++ lib/Crypto/SelfTest/PublicKey/test_RSA.py
+@@ -393,7 +393,7 @@ def get_tests(config={}):
+         from Crypto.PublicKey import _fastmath
+         tests += list_test_cases(RSAFastMathTest)
+     except ImportError:
+-        from distutils.sysconfig import get_config_var
++        from sysconfig import get_config_var
+         import inspect
+         _fm_path = os.path.normpath(os.path.dirname(os.path.abspath(
+             inspect.getfile(inspect.currentframe())))
+--- lib/Crypto/Util/number.py
++++ lib/Crypto/Util/number.py
+@@ -41,7 +41,7 @@ except ImportError:
+     # see an exception raised if _fastmath exists but cannot be imported,
+     # uncomment the below
+     #
+-    # from distutils.sysconfig import get_config_var
++    # from sysconfig import get_config_var
+     # import inspect, os
+     # _fm_path = os.path.normpath(os.path.dirname(os.path.abspath(
+         # inspect.getfile(inspect.currentframe())))
+--- setup.py
++++ setup.py
+@@ -1,6 +1,6 @@
+ #! /usr/bin/env python
+ #
+-#  setup.py : Distutils setup script
++#  setup.py : setuptools setup script
+ #
+ #  Part of the Python Cryptography Toolkit
+ #
+@@ -36,11 +36,10 @@
+ 
+ __revision__ = "$Id$"
+ 
+-from distutils import core
+-from distutils.ccompiler import new_compiler
+-from distutils.core import Extension, Command
+-from distutils.command.build import build
+-from distutils.command.build_ext import build_ext
++from setuptools import setup
++from setuptools.command.build_ext import new_compiler
++from setuptools import Extension, Command
++from setuptools.command.build_ext import build_ext
+ import os, sys, re
+ import struct
+ 
+@@ -53,8 +52,7 @@ if sys.version[0:1] != '3':
+ # .gcov files
+ USE_GCOV = 0
+ 
+-
+-from distutils.command.build_py import build_py
++from setuptools.command.build_py import build_py
+ 
+ # Work around the print / print() issue with Python 2.x and 3.x. We only need
+ # to print at one point of the code, which makes this easy
+@@ -385,7 +383,7 @@ kw = {'name':"pycrypto",
+     ]
+ }
+ 
+-core.setup(**kw)
++setup(**kw)
+ 
+ def touch(path):
+     import os, time
diff --git a/python-crypto.spec b/python-crypto.spec
index 77cfcd6..4fa57e0 100644
--- a/python-crypto.spec
+++ b/python-crypto.spec
@@ -23,12 +23,14 @@ Patch7:		pycrypto-2.6.1-drop-py2.1-support.patch
 Patch8:		python-crypto-2.6.1-python3.10.patch
 Patch9:		python-crypto-2.6.1-python3.11.patch
 Patch10:	python-crypto-2.6.1-python3only.patch
+Patch11:	python-crypto-2.6.1-no-distutils.patch
 BuildRequires:	coreutils
 BuildRequires:	findutils
 BuildRequires:	gcc
 BuildRequires:	gmp-devel >= 4.1
 BuildRequires:	libtomcrypt-devel >= 1.16
 BuildRequires:	python%{python3_pkgversion}-devel
+BuildRequires:	python%{python3_pkgversion}-setuptools
 
 %description
 PyCrypto is a collection of both secure hash functions (such as MD5 and
@@ -97,6 +99,9 @@ rm -rf src/libtom
 # Convert all code to Python 3 before the ability to use 2to3 goes away
 %patch10
 
+# Drop use of deprecated distutils, going away in Python 3.12
+%patch11
+
 %build
 %global optflags %{optflags} -fno-strict-aliasing
 %py3_build
@@ -122,6 +127,7 @@ PYTHONPATH=%{buildroot}%{python3_sitearch} %{__python3} pct-speedtest.py
 %changelog
 * Thu Nov 11 2021 Paul Howarth <paul@city-fan.org> - 2.6.1-38
 - Convert all code to Python 3 before the ability to use 2to3 goes away
+- Drop use of deprecated distutils, going away in Python 3.12
 
 * Wed Nov 10 2021 Paul Howarth <paul@city-fan.org> - 2.6.1-37
 - Fix Python 3.11 compatibility (#2021808)